Effects of apoptosis and lipid peroxidation on T-lymphoblastoid phospholipid-dependent procoagulant activity.

@article{Pickering2008EffectsOA,
  title={Effects of apoptosis and lipid peroxidation on T-lymphoblastoid phospholipid-dependent procoagulant activity.},
  author={W. Roy Pickering and Elaine Gray and Alison H. Goodall and Trevor W. Barrowcliffe},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 7},
  pages={1122-30}
}
BACKGROUND Coagulation has an absolute requirement for macromolecular complexes to be assembled on a negatively charged phospholipid (PL) surface. Previously, we reported that malignant T-lymphoblastoid cells have the ability to support procoagulant activity (PCA) independently of tissue factor by providing such a surface. OBJECTIVE To explore the effect of two pathophysiologic processes, apoptosis and lipid peroxidation (LP), on this PL-dependent PCA. METHODS Three different assays for PL… CONTINUE READING