Effects of apomorphine on globus pallidus neurons in parkinsonian patients.

  title={Effects of apomorphine on globus pallidus neurons in parkinsonian patients.},
  author={Wesley Hutchinson and Ronald Levy and Jonathan O. Dostrovsky and Andres M. Lozano and Anthony E Lang},
  journal={Annals of neurology},
  volume={42 5},
Current hypotheses of basal ganglia dysfunction in Parkinson's disease (PD) propose that neuronal hypoactivity in the globus pallidus externus (GPe), and hyperactivity in the output nuclei and the external and internal portions of the globus pallidus internus (GPi,e and GPi,i, respectively), result in the cardinal symptoms of PD. To test this theory, the nonselective D1- and D2-dopamine receptor agonist apomorphine (30-100 microg/kg SC) was administered to 14 levodopa-responsive PD patients who… CONTINUE READING
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