Effects of aphidicolin on repair replication and induced chromosomal aberrations in mammalian cells.


The influence of aphidicolin, an inhibitor of polymerase alpha, on UV-induced repair replication in human skin fibroblasts, as well as in HeLa cells, was determined. In growing fibroblasts and in HeLa cells, aphidicolin had a potentiating effect on UV-induced repair replication, whereas in fibroblasts grown to confluency, aphidicolin had an inhibitory… (More)


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