Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?

Abstract

The effects of the two representatives of the antitumor transplatinum agents, trans-[PtCl2(methylamine)2] and trans-[PtCl2(NH3)(1-methyl-7-azaindole)] on bacterial growth were examined. The results show that these antitumor transplatinum agents can be grouped with the coordination Pt(II) compounds exhibiting antitumor activity and capable of inducing… (More)
DOI: 10.1016/j.jinorgbio.2015.07.014

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