Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.

@article{Korotkova2005EffectsOA,
  title={Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.},
  author={Marina N. Korotkova and Marie Westman and Karina Roxana Gheorghe and Erik af Klint and Christina Trollmo and Ann Kristin Ulfgren and Lars Klareskog and P. -J. Jakobsson},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 11},
  pages={3439-47}
}
OBJECTIVE Microsomal prostaglandin E synthase 1 (mPGES-1) is up-regulated in experimental arthritis and markedly expressed in synovial tissue biopsy samples from patients with rheumatoid arthritis (RA). This study was carried out to determine the effects of tumor necrosis factor (TNF) blockers and glucocorticoids on mPGES-1 and cyclooxygenase (COX) expression, as well as biosynthesis of PGE(2) in rheumatoid joints. METHODS In vitro effects of TNF blockers and dexamethasone on the PGE(2… CONTINUE READING