Effects of antipsychotics on prepulse inhibition of the startle response in drug-naïve schizophrenic patients.

@article{Mackeprang2002EffectsOA,
  title={Effects of antipsychotics on prepulse inhibition of the startle response in drug-na{\"i}ve schizophrenic patients.},
  author={Torben Mackeprang and Klaus Tjelle Kristiansen and Birte Y. Glenthoj},
  journal={Biological psychiatry},
  year={2002},
  volume={52 9},
  pages={863-73}
}
BACKGROUND Disturbances in sensorimotor gating measured by prepulse inhibition of the startle response (PPI) have frequently been reported in medicated and unmedicated schizophrenia spectrum patients and in their relatives, suggesting that the deficit represents a stable vulnerability marker for schizophrenia. Clinical data on the effects of antipsychotics on PPI disturbances are scarce, but from preclinical studies, antipsychotics have been shown to influence PPI. To differentiate pathogenetic… CONTINUE READING
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