Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats.

@article{Calzavara2011EffectsOA,
  title={Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats.},
  author={Mariana Bendlin Calzavara and Raquel Levin and Wladimir Agostini Medrano and Val{\'e}ria Almeida and Ant{\^o}nio Pereira Fr{\'o}is Sampaio and Lucas Cerqueira Barone and Roberto Frussa-Filho and Vanessa Costhek Ab{\'i}lio},
  journal={Behavioural brain research},
  year={2011},
  volume={225 1},
  pages={15-22}
}

• Mariana Bendlin Calzavara, Raquel Levin, +5 authors Vanessa Costhek Abílio
• Published 2011 in Behavioural brain research
• DOI:10.1016/j.bbr.2011.06.026

We have recently reported that spontaneously hypertensive rats (SHRs) exhibit a deficit in contextual fear conditioning that is specifically reversed by antipsychotic and potentiated by psychostimulants and other manipulations thought to produce schizophrenia-like states in rodents. Based on these findings, we suggested that this deficit in fear conditioning could be used as an experimental model of emotional processing impairments observed in schizophrenia. This strain has also been suggested… CONTINUE READING

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