Effects of antineoplastic agents on wound healing in mice.

  title={Effects of antineoplastic agents on wound healing in mice.},
  author={Steven A. Cohen and Henry L. Gabelnick and Randall K. Johnson and Abraham Goldin},
  volume={78 2},
The influence of antineoplastic agents on wound healing was evaluated in an experimental model employing surgical incisions in the skin of mice. A single injection in the therapeutic dose range of various clinically active antitumor agents was administered immediately following operation and the breaking strength of skin wounds was measured 3, 7, and 21 days later. Vincristine and methotrexate decreased wound strength at 3 days but not on days 7 or 21. Actinomycin D interfered with early phases… CONTINUE READING


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