Effects of antigen dosage on early localization of specific antibodies in rat splenic germinal centers.

In order to identify the initial site of antibody formation in rat spleen, an investigation was made to determine the effects of different antigen dosages on the localization of specific antibodies against sheep erythrocytes (SRBCs). Sixty rats were intravenously injected with 1 ml of either 1%, 5%, or 10% suspensions of SRBCs and killed at days 1, 2, 3… CONTINUE READING