Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice.

@article{Moore2002EffectsOA,
  title={Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice.},
  author={Anne C Moore and Wing-pui Kong and Bimal K. Chakrabarti and Gary J. Nabel},
  journal={Journal of virology},
  year={2002},
  volume={76 1},
  pages={243-50}
}
The effects of genetic adjuvants on humoral and cell-mediated immunity to two human immunodeficiency virus antigens, Env and Nef, have been examined in mice. Despite similar levels of gene expression and the same gene delivery vector, the immune responses to these two gene products differed following DNA immunization. Intramuscular immunization with a Nef expression vector plasmid generated a humoral response and antigen-specific gamma interferon (IFN-gamma) production but little cytotoxic-T… CONTINUE READING
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