Effects of antiepileptic drugs on pentylenetetrazole-induced epileptiform activity in the in vitro hippocampus.

@article{Piredda1986EffectsOA,
  title={Effects of antiepileptic drugs on pentylenetetrazole-induced epileptiform activity in the in vitro hippocampus.},
  author={Salvatore G. Piredda and Wayne D. Yonekawa and Tim S. Whittingham and Harvey J. Kupferberg},
  journal={Epilepsia},
  year={1986},
  volume={27 4},
  pages={
          341-6
        }
}
We studied the effects of four antiepileptic drugs on pentylenetetrazole-induced burst discharges in the CA3 region of the in vitro hippocampus. Diazepam and carbamazepine abolished the bursting activity in a gradual and dose-dependent manner. Phenobarbital only decreased the burst frequency. Valproic acid was either ineffective or actually caused an increase in both burst frequency and amplitude. The findings in this model were compared with results obtained by other investigators in a… CONTINUE READING
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