Effects of antiepileptic drugs on associative LTP‐like plasticity in human motor cortex

  title={Effects of antiepileptic drugs on associative LTP‐like plasticity in human motor cortex},
  author={T. Heidegger and K. Krakow and U. Ziemann},
  journal={European Journal of Neuroscience},
  • T. Heidegger, K. Krakow, U. Ziemann
  • Published 2010
  • Psychology, Medicine
  • European Journal of Neuroscience
  • Antiepileptic drugs (AEDs) are used extensively in clinical practice but relatively little is known on their specific effects at the systems level of human cortex. Here we tested, using a double‐blind randomized placebo‐controlled crossover design in healthy subjects, the effects of a single therapeutic oral dose of seven AEDs with different modes of action (tiagabine, diazepam, gabapentin, lamotrigine, topiramate, levetiracetam and piracetam) on long‐term potentiation (LTP)‐like motor cortical… CONTINUE READING
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