Effects of antiepileptic drugs on associative LTP-like plasticity in human motor cortex.

@article{Heidegger2010EffectsOA,
  title={Effects of antiepileptic drugs on associative LTP-like plasticity in human motor cortex.},
  author={Tonio Heidegger and K. Krakow and Ulf Ziemann},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 7},
  pages={
          1215-22
        }
}
Antiepileptic drugs (AEDs) are used extensively in clinical practice but relatively little is known on their specific effects at the systems level of human cortex. Here we tested, using a double-blind randomized placebo-controlled crossover design in healthy subjects, the effects of a single therapeutic oral dose of seven AEDs with different modes of action (tiagabine, diazepam, gabapentin, lamotrigine, topiramate, levetiracetam and piracetam) on long-term potentiation (LTP)-like motor cortical… CONTINUE READING

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