Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes

@article{Kammerer2011EffectsOA,
  title={Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes},
  author={Miriam Kammerer and Michael P. Rassner and Thomas M. Freiman and Thomas J. Feuerstein},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2011},
  volume={384},
  pages={47-57}
}
In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs (AEDs) are thought to increase GABA release. Because little is known about corresponding presynaptic effects of AEDs in the human brain, this study investigated the effects of carbamazepine, lamotrigine, phenytoin, gabapentin, pregabalin, levetiracetam, and valproate on 3H-GABA release from human neocortical synaptosomes preincubated with 3H… 
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