Effects of antidepressant treatment on neuroactive steroids in major depression.

  title={Effects of antidepressant treatment on neuroactive steroids in major depression.},
  author={Elena Romeo and Andreas Str{\"o}hle and Gianfranco Spalletta and Flavia di Michele and Bettina Hermann and Florian Holsboer and Augusto Pasini and Rainer Rupprecht},
  journal={The American journal of psychiatry},
  volume={155 7},
OBJECTIVE There is evidence from animal studies that fluoxetine may enhance the concentrations of neuroactive steroids. Therefore, the authors investigated whether clinically effective treatment with antidepressants may alter the concentrations of neuroactive steroids in patients suffering from a major depressive episode. METHOD In the first study, eight drug-naive outpatients with major depression were studied during treatment with fluoxetine. In a complementary study, 11 inpatients with… CONTINUE READING
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