Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.

@article{Sawaki2000EffectsOA,
  title={Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.},
  author={K. Sawaki and Kazushige Ohno and Ken-ichiro Miyamoto and Shinichiro Hirai and Kenji Yazaki and Mitsuru Kawaguchi},
  journal={Pharmacology & toxicology},
  year={2000},
  volume={86 2},
  pages={59-62}
}
The effects of various anticonvulsants on local anaesthetics procaine- and lidocaine-induced convulsions were investigated in rats. Pretreatment with diazepam (2.5-5 mg/kg, intraperitoneally) and clonazepam (5-10 mg/kg, intraperitoneally) completely protected the rats against both local anaesthetic-induced convulsions. Phenobarbital (12.5-50 mg/kg, subcutaneously) also significantly decreased the incidence of both convulsions and prolonged their latencies. Carbabazepine (10-40 mg/kg… CONTINUE READING