Effects of anticonvulsants and methotrexate on calcium disposition

@article{Evans1980EffectsOA,
  title={Effects of anticonvulsants and methotrexate on calcium disposition},
  author={M. Evans},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1980},
  volume={315},
  pages={63-67}
}
  • M. Evans
  • Published 1980
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • SummaryAdministration of phenytoin for 5 days significantly reduces oral absorption and bone uptake of radiolabelled calcium in mice. Acute treatment with phenytoin had no effect on calcium disposition. Pretreatment (1–5 days) with phenobarbital also had no effect of calcium disposition. Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance. It is concluded that phenytoin induced reduction in calcium metabolism… CONTINUE READING

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    Anticonvulsant Drugs and Calcium Metabolism
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