Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice

@article{Yamaguchi1992EffectsOA,
  title={Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice},
  author={Shun-ichi Yamaguchi and Michael A. Rogawski},
  journal={Epilepsy Research},
  year={1992},
  volume={11},
  pages={9-16}
}
Electrophysiological and behavioral properties of 4-aminopyridine-induced epileptic activity in mice.
TLDR
It is concluded that the intraperitoneal administration of 4-AP at a dose of 10 mg/kg induces explicit seizure activity in mice which is repeatable and can be suitable for further molecular research.
Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents
Effect of the Anti-depressant Sertraline, the Novel Anti-seizure Drug Vinpocetine and Several Conventional Antiepileptic Drugs on the Epileptiform EEG Activity Induced by 4-Aminopyridine
TLDR
4-AP is a useful tool to elicit the mechanism of action of anti-seizure drugs at clinical meaningful doses and sertraline and vinpocetine are explained by their high effectiveness to reduce brain presynaptic Na+ and Ca2+ channels permeability.
VERAPAMIL INTERFERES WITH THE ANTICONVULSANT EFFECT OF MORPHIN IN A STRYECHNINE INDUCED CONVULSION MODEL IN MICE
TLDR
The reduced anticonvulsant effect of morphine by verapamil seems to be because of increase in morphine concentration in brain, which is mediated through different mechanisms.
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The results suggest that the modulation of the calcium influx in the CNS might influence the epileptic phenomena.
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The present observations suggest that the anticonvulsant effect of taurine might be mediated by 4‐AP‐calcium‐taurine interactions.
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