Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice

@article{Yamaguchi1992EffectsOA,
  title={Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice},
  author={Shun-ichi Yamaguchi and Michael A. Rogawski},
  journal={Epilepsy Research},
  year={1992},
  volume={11},
  pages={9-16}
}
The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s.c.). We evaluated the ability of a series of anticonvulsant drugs to protect against 4-AP-induced seizures using lethality as the endpoint. Drugs with a phenytoin-like profile of activity were… 
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TLDR
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TLDR
DCS potentiates the anticonvulsant action of some classical antiepileptic drugs, most notably diazepam, phenobarbital, phenytoin and valproate, and the therapeutic index of the combined treatment of the above drugs+DCS, was more favourable than the same drugs+saline.
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