Effects of anticancer platinum compounds on Escherichia coli strains with normal and defective DNA repair capacity.

Abstract

The effect of anticancer platinum compounds on isogenetic strains of Escherichia coli with normal or defective DNA repair capacity were studied. Cisdichlorodiammineplatinum (II) causes DNA damage that is repairable by the repair systems of bacteria, and the DNA lesion becomes mutational when processed by the excision repair system. Dinitrato (1R, 2S… (More)

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