Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold.

@article{Murakawa1989EffectsOA,
  title={Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold.},
  author={Yuji Murakawa and Iku Toda and Akira Nozaki and Kiyoshi Kawakubo and Taro Sugimoto},
  journal={Cardiology},
  year={1989},
  volume={76 1},
  pages={58-66}
}
The effects of class 1 antiarrhythmic drugs on the repetitive extrasystole threshold (RET) and the ventricular fibrillation threshold (VFT) were studied in 32 anesthetized dogs with localized transmural necrosis. All four drugs significantly increased VFT. Although lidocaine and mexiletine increased RET, procainamide and disopyramide did not. We conclude… CONTINUE READING