Effects of anthrapyrazole antineoplastic agents on lipid peroxidation.

Abstract

The effects of three anthrapyrazoles and an aminoacridine derivative on doxorubicin- and iron-stimulated lipid peroxidation in rabbit hepatic microsomes have been characterized. Two anthrapyrazoles, CI-937 and CI-942, were potent inhibitors of lipid peroxidation with 15 microM drug inhibiting the rate of peroxidation 70 to 90%. In contrast CI-941 was… (More)

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Cite this paper

@article{Frank1986EffectsOA, title={Effects of anthrapyrazole antineoplastic agents on lipid peroxidation.}, author={Paul Frank and Rostislav Novak}, journal={Biochemical and biophysical research communications}, year={1986}, volume={140 3}, pages={797-807} }