Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation.

@article{Shum2001EffectsOA,
  title={Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation.},
  author={Kathy Shum and Kaoru Inouye and Owen S. Chan and Julian Mathoo and D L Bilinski and Stephen G. Matthews and Mladen Vranic},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 3},
  pages={E455-65}
}
This study aimed to differentiate the effects of repeated antecedent hypoglycemia, antecedent marked hyperinsulinemia, and antecedent increases in corticosterone on counterregulation to subsequent hypoglycemia in normal rats. Specifically, we examined whether exposure to hyperinsulinemia or elevated corticosterone per se could impair subsequent counterregulation. Four groups of male Sprague-Dawley rats were used: 1) normal controls (N) had 4 days of sham antecedent treatment; 2) an antecedent… CONTINUE READING

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