Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.

@article{Webb2003EffectsOA,
  title={Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.},
  author={Serena D Webb and Jeffrey L. Cleland and John F. Carpenter and Theodore W. Randolph},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 4},
  pages={715-29}
}
The purpose of this study was to examine the effects of adsorption of recombinant human interferon-gamma (rhIFN-gamma) on ice surfaces and subsequent drying during processing by spray-lyophilization and lyophilization. Ice/liquid interfacial areas were manipulated by the freezing method as well as by the addition of an annealing step during lyophilization… CONTINUE READING