Effects of anisotropy on the development of cardiac arrhythmias associated with focal activity

@article{Wilders2000EffectsOA,
  title={Effects of anisotropy on the development of cardiac arrhythmias associated with focal activity},
  author={Ronald Wilders and Mary B. Wagner and David A. Golod and Rajiv B. Kumar and Yang-Gan Wang and William N. Goolsby and Ronald W. Joyner and Habo J. Jongsma},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={441},
  pages={301-312}
}
The anisotropy that normally exists in the myocardium may be either enhanced in peri-infarction zones by loss of lateral cell connections or reduced by redistribution of gap junctions. To test how the degree of anisotropy affects the development of ectopic focal activity, we carried out computer simulations in which a model of an ectopic focus is incorporated as the central element of a two-dimensional sheet of ventricular cells. At low values of intercellular coupling conductance (G c), the… CONTINUE READING

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