Effects of anion proximity in peptide primary sequence on the rate and mechanism of leucine oxidation.

@article{Sharp2006EffectsOA,
  title={Effects of anion proximity in peptide primary sequence on the rate and mechanism of leucine oxidation.},
  author={Joshua S Sharp and Kenneth B. Tomer},
  journal={Analytical chemistry},
  year={2006},
  volume={78 14},
  pages={4885-93}
}
Hydroxyl radical surface mapping is a useful tool for investigating protein structure and folding. The rate of protein side-chain oxidation by the hydroxyl radical is known to be affected primarily by the chemical reactivity of the side chain and the accessibility of the reactive site to the radical. Efforts have been made to determine the inherent rate of stable product formation of each amino acid side chain, so that the rate of oxidation of an amino acid can be used to accurately estimate… CONTINUE READING

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