Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats.

Abstract

BACKGROUND The fawn-hooded hypertensive (FHH) rat develops spontaneous glomerulosclerosis that is ameliorated by inhibition of the angiotensin II type 1 receptor (AT-1). Since kidney damage is associated with nitric oxide (NO) deficiency, we investigated how AT-1 antagonism influenced nitric oxide synthase (NOS), as well as NOS substrate [L-arginine (L-Arg… (More)
DOI: 10.1093/ndt/gfq272

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@article{Chen2010EffectsOA, title={Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats.}, author={G Chen and Laszlo J. Wagner and Jennifer M. Sasser and Sergey S. Zharikov and Natasha C Moningka and Chris Baylis}, journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}, year={2010}, volume={25 11}, pages={3518-25} }