Effects of angiotensin-converting enzyme inhibitors on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary disease.

@article{Teramoto2000EffectsOA,
  title={Effects of angiotensin-converting enzyme inhibitors on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary disease.},
  author={Shinji Teramoto and Masao Suzuki and Takeshi Matsuse and Takeo Ishii and Yoshinosuke Fukuchi and Yasuyoshi Ouchi},
  journal={Japanese journal of pharmacology},
  year={2000},
  volume={83 1},
  pages={56-62}
}
We examined the effects of angiotensin-converting enzyme (ACE) inhibitors on spontaneous or stimulated generation of reactive oxygen species (ROS) by bronchoalveolar lavage (BAL) cells prepared from 6 patients with chronic obstructive pulmonary disease (COPD) and from age-matched control subjects without COPD. The ROS produced by BAL cells were measured by the lucigenin-dependent chemiluminescence method. The application of ACE inhibitors into culture media containing BAL cells inhibited… CONTINUE READING