Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension.

@article{Wang2015EffectsOA,
  title={Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension.},
  author={Xian-min Wang and Kun Shi and Jinhua Li and T T Chen and Yuxuan Guo and Yi-ling Liu and Yan-feng Yang and Shaobao Yang},
  journal={Genetics and molecular research : GMR},
  year={2015},
  volume={14 1},
  pages={1707-17}
}
This study investigated the effects of angiotensin II (AngII) intervention, using captopril and losartan, on the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen in rats with pulmonary hypertension, in an effort to understand mechanisms underlying pulmonary vascular remodeling. A total of 40 male Sprague-Dawley rats were randomly divided into normal group, model group, captopril group, and losartan group. After 5 weeks, the… CONTINUE READING
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