Effects of aneuploidy on gene expression: implications for cancer.

  title={Effects of aneuploidy on gene expression: implications for cancer.},
  author={Milena D{\"u}rrbaum and Zuzana Storchov{\'a}},
  journal={The FEBS journal},
  volume={283 5},
Unbalanced chromosome content, so-called aneuploidy, is a hallmark of cancer cells. Changes in the copy numbers of chromosomes or large chromosomal regions significantly alter the expression of several hundreds of genes that are gained or lost. At the same time, aneuploidy per se affects the transcription of many genes throughout the entire genome, as several pathways are activated or inhibited in response to changes in chromosome copy number. In recent years, a large amount of quantitative… CONTINUE READING
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