Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes.

@article{Ogata2006EffectsOA,
  title={Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes.},
  author={Junichi Ogata and Munehiro Shiraishi and Tsunehisa Namba and Corigan Thetford Smothers and John J Woodward and R. Adron Harris},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={318 1},
  pages={434-43}
}
Alcohols, inhaled anesthetics, and some injectable anesthetics inhibit the function of N-methyl-d-aspartate (NMDA) receptors, but the mechanisms responsible for this inhibition are not fully understood. Recently, it was shown that ethanol inhibition of NMDA receptors was reduced by mutation of residues in the transmembrane (TM) segment 3 of the NR1 subunit (F639A) or in TM4 of the NR2A subunit (A825W), suggesting putative ethanol binding sites. We hypothesized that the actions of other… CONTINUE READING
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