Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells.

@article{Greisen2001EffectsOA,
  title={Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells.},
  author={Susanne Greisen and Thomas Ledet and Per Glud Ovesen},
  journal={Human reproduction},
  year={2001},
  volume={16 10},
  pages={
          2061-5
        }
}
BACKGROUND The present study was conducted to investigate the effect of androstenedione, insulin and LH on human granulosa cell oestrogen and progesterone production. We postulated that elevated concentrations of androstenedione, insulin and LH may be important modulators of granulosa cell steroidogenesis. METHODS Granulosa cells obtained in connection with IVF procedures were cultured for a total of 4 days in serum-free medium containing androstenedione (10(-6) mol/l). We tested the effect… CONTINUE READING

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