Effects of an unnatural base pair replacement on the structure and dynamics of DNA and neighboring water and ions.

Abstract

Incorporating small molecule probes into biomolecular systems to report on local structure and dynamics is a powerful strategy that underlies a wide variety of experimental techniques, including fluorescence, electron paramagnetic resonance (EPR), and Forster resonance energy transfer (FRET) measurements. When an unnatural probe is inserted into a protein… (More)
DOI: 10.1021/jp105761b

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