Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.

Abstract

The effects of an endothelin ET(A)-receptor selective antagonist, S-0139, were examined using dogs given endothelin-1 (ET-1) into the subarachnoid space. ET-1 at 40 pmol apparently constricted the basilar artery in anesthetized dogs and caused various grades of ataxia, facial clonus, nystagmus and other features in conscious dogs, partially mimicking those… (More)

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@article{Sato1998EffectsOA, title={Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1.}, author={S. Sato and Yoshiyuki Yonetani and M. Stanley Fujimoto and Takashi Kita and K. Kubo and T. Nakashima}, journal={Life sciences}, year={1998}, volume={62 13}, pages={PL191-7} }