Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole.

  title={Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole.},
  author={Thomas W F Chin and Mark Loeb and Ignatius William Fong},
  journal={Antimicrobial agents and chemotherapy},
  volume={39 8},
Absorption of ketoconazole is impaired in patients with achlorhydria. The purpose of this study was to determine the effectiveness of a palatable acidic beverage (Coca-Cola Classic, pH 2.5) in improving the absorption of ketoconazole in the presence of drug-induced achlorhydria. A prospective, randomized, three-way crossover design with a 1-week wash-out period between each treatment was employed. Nine healthy nonsmoking, nonobese volunteers between 22 and 41 years old were studied. Each… CONTINUE READING
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