Effects of an Unlabeled Loading Dose on Tumor-Specific Uptake of a Fluorescently Labeled Antibody for Optical Surgical Navigation

@article{Moore2016EffectsOA,
  title={Effects of an Unlabeled Loading Dose on Tumor-Specific Uptake of a Fluorescently Labeled Antibody for Optical Surgical Navigation},
  author={Lindsay Shannon Moore and Eben L Rosenthal and E. C.S. de Boer and Andrew C Prince and Neel Patel and Joshua Richman and Anthony B.P. Morlandt and William R. Carroll and Kurt R Zinn and Jason M. Warram},
  journal={Molecular Imaging and Biology},
  year={2016},
  volume={19},
  pages={610-616}
}
PurposeIntraoperative optical imaging to guide surgeons during oncologic resections offers a unique and promising solution to the ambiguity of cancer margins to tactile and visual assessment that results in devastatingly high rates of positive margins. Sequestering of labeled antibodies by normal tissues with high expression of the antibody target, or “antigen sinks”, diminishes the efficacy of these probes to provide contrast between the tumor and background tissues by decreasing the amount of… CONTINUE READING
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