Effects of an Rb mutation in the mouse.


The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele… (More)


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@article{Jacks1992EffectsOA, title={Effects of an Rb mutation in the mouse.}, author={Tyler E. Jacks and Anita Fazeli and Earlene M. Schmitt and Roderick Terry Bronson and Margaret A. Goodell and Rebecca Weinberg}, journal={Nature}, year={1992}, volume={359 6393}, pages={295-300} }