Effects of an EP2 and EP3 Receptor Dual Agonist, ONO-8055, on a Radical Hysterectomy-Induced Underactive Bladder Model in Monkeys.

Abstract

OBJECTIVES The objective was to develop an underactive bladder (UAB) model in primates and to evaluate the potential of prostanoid EP2 and EP3 receptor dual agonist ONO-8055 to become a therapeutic agent for UAB. METHODS A surgical procedure resembling radical hysterectomy was performed on female cynomolgus monkeys. Subsequently, in vitro muscle strip… (More)
DOI: 10.1111/luts.12166

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Cite this paper

@article{Matsuya2017EffectsOA, title={Effects of an EP2 and EP3 Receptor Dual Agonist, ONO-8055, on a Radical Hysterectomy-Induced Underactive Bladder Model in Monkeys.}, author={Hidekazu Matsuya and Noritoshi Sekido and Jun Kida and Hiroko Mashimo and Daisuke Wakamatsu and Hiroki Okada}, journal={Lower urinary tract symptoms}, year={2017} }