Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

@inproceedings{Noveck2014EffectsOA,
  title={Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers},
  author={Robert J Noveck and Erik S. G. Stroes and Joann D Flaim and Brenda F. Baker and Steve H. Hughes and Mark J. Graham and Rosanne M. Crooke and Paul M. Ridker},
  booktitle={Journal of the American Heart Association},
  year={2014}
}
BACKGROUND C-reactive protein (CRP) binds to damaged cells, activates the classical complement pathway, is elevated in multiple inflammatory conditions, and provides prognostic information on risk of future atherosclerotic events. It is controversial, however, as to whether inhibiting CRP synthesis would have any direct anti-inflammatory effects in humans. METHODS AND RESULTS A placebo-controlled study was used to evaluate the effects of ISIS 329993 (ISIS-CRPR x) on the acute-phase response… CONTINUE READING