Effects of an Adaptogen-Based Supplement on Stress Parameters in Healthy Volunteers

@article{Shara2017EffectsOA,
  title={Effects of an Adaptogen-Based Supplement on Stress Parameters in Healthy Volunteers},
  author={Mohd A. Shara and E Kakish and Sidney J Stohs},
  journal={International Journal of Complementary and Alternative Medicine},
  year={2017},
  volume={10}
}
  • M. Shara, E. Kakish, S. Stohs
  • Published 12 December 2017
  • Medicine
  • International Journal of Complementary and Alternative Medicine
According to the American Institute of Stress, over 70 % of people regularly experience physical and/or psychological symptoms caused by stress. The primary causes of stress in decreasing order of occurrence are: job pressure, money, health, relationships, poor nutrition, media overload, and sleep deprivation [1]. Persistent stress leads to fatigue, irritability, insomnia, weakened immune system, and increased susceptibility various diseases including cardiovascular diseases. Annual cost to… 

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References

SHOWING 1-10 OF 26 REFERENCES
Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
TLDR
The aim of this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified effects of Rhodiola rosea SHR-5 extract.
Adaptogenic Potential of a Polyherbal Natural Health Product: Report on a Longitudinal Clinical Trial
  • D. SeelyRana Singh
  • Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2007
TLDR
Initial evidence for this polyherbal compound, OCTA©, a compound mixture of eight herbs, supports its potential as an effective ‘adaptogenic’ aid in dealing with stress.
Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity
TLDR
A number of clinical trials demonstrate that adaptogens exert an anti-fatigue effect that increases mental work capacity against a background of stress and fatigue, particularly in tolerance to mental exhaustion and enhanced attention.
The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity
TLDR
Findings implicate that obesity, stress and sleep loss are all related in a vicious circle and new strategies to combat obesity through modulating cortisol levels in adipose tissue by 11β-HSD1 inhibitors or by improving sleep duration are discussed.
The metabolic syndrome and inflammation.
TLDR
The general goals of treatment of the MS are prevention of CHD events and diabetes if not already present, and the approach to treatment of those with the MS should include lifestyle changes, including weight loss and exercise as well as appropriate pharmacological therapies.
Interrelationships between inflammation, C-reactive protein, and insulin resistance.
TLDR
Discussion is led about the addition of hs-CRP measurement to the current definition of the cardiometabolic syndrome to improve detection of risk for both diabetes and cardiovascular events in patients.
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
TLDR
The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life.
Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress.
CRP and the risk of atherosclerotic events
TLDR
The identification of specific triggers and mechanisms of underlying inflammation and a better understanding of each step involved in this complex process might lead to new ways to manage patients with atherosclerosis, and CRP still appears to be a suitable candidate for this purpose.
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