Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia

  title={Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia},
  author={Byoung Seok Ye and Sang Won Seo and Jung-Hyun Kim and Geon Ha Kim and Hanna Cho and Young Noh and Hee Jin Kim and Cindy W Yoon and Sook-Young Woo and Sook Hui Kim and Hee Kyung Park and Sung Tae Kim and Yearn Seong Choe and Kyung-Han Lee and Jae Seung Kim and Seung Jun Oh and Changsoo Kim and Michael W Weiner and Jae-Hong Lee and Duk L. Na},
  pages={1687 - 1693}
Objective: To determine the independent and synergistic effects of amyloid and small vessel disease (SVD) burden on longitudinal cognitive decline in patients with subcortical vascular dementia (SVaD). Methods: A longitudinal cohort study was conducted involving patients from outpatient clinics of 2 tertiary referral centers. Sixty-one patients with SVaD were prospectively recruited and underwent MRI, 11C–Pittsburgh compound B (PiB) PET at baseline, and a 3-year annual neuropsychological follow… 

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