Effects of amyloid-β plaque proximity on the axon initial segment of pyramidal cells.

@article{LenEspinosa2012EffectsOA,
  title={Effects of amyloid-β plaque proximity on the axon initial segment of pyramidal cells.},
  author={Gonzalo Le{\'o}n-Espinosa and Javier DeFelipe and Alberto Mu{\~n}oz},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={29 4},
  pages={841-52}
}
The output of cortical pyramidal cells reflects the balance between excitatory inputs of cortical and subcortical origin, and inhibitory inputs from distinct populations of cortical GABAergic interneurons, each of which selectively innervate different domains of neuronal pyramidal cells (i.e., dendrites, soma and axon initial segment [AIS]). In Alzheimer's disease (AD), the presence of amyloid-β (Aβ) plaques alters the synaptic input to pyramidal cells in a number of ways. However, the effects… CONTINUE READING
7 Citations
0 References
Similar Papers