Effects of amphotericin B on macrophages and their precursor cells.

  title={Effects of amphotericin B on macrophages and their precursor cells.},
  author={Sue Hwa Lin and Gerald Medoff and George S. Kobayashi},
  journal={Antimicrobial agents and chemotherapy},
  volume={11 1},
The effect of amphotericin B (AmB) treatment on the mononuclear phagocyte system of mice was investigated. Peritoneal macrophages from mice that received AmB treatment showed a higher phagocytic and antibacterial activity than those from normal untreated mice. When the levels of macrophage precursor cells in bone marrow and spleen were followed in mice after AmB treatment, an eightfold increase in the splenic content of limited stem cells for both macrophages and granulocytes (colony-forming… CONTINUE READING


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