Effects of amphiphiles on erythrocytes, coronary arteries, and perfused hearts.

@article{Bergmann1981EffectsOA,
  title={Effects of amphiphiles on erythrocytes, coronary arteries, and perfused hearts.},
  author={S. R. Bergmann and Thomas Bruce Ferguson and B. E. Sobel},
  journal={The American journal of physiology},
  year={1981},
  volume={240 2},
  pages={H229-37}
}
Due to their unique structure, lysophosphoglycerides (such as lysophosphatidylcholine, LPC), compounds known to accumulate in ischemic myocardium, form micelles at concentrations exceeding the critical micelle concentration (CMC). In this study, we found that sub-CMC levels of LPC exerted dose-dependent morphological changes on red blood cells and elicited dysrhythmia and contracture while increasing coronary artery resistance in isolated hearts. LPC at supra-CMC concentrations lysed red blood… CONTINUE READING

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