Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats.

  title={Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats.},
  author={K. Ajeigbe and S. Olaleye and E. Nwobodo},
  journal={Pakistan journal of biological sciences : PJBS},
  volume={11 17},
In this study, the effects of two antimalarials-amodiaquine hydrochloride and artemisinin were investigated in ulcerated albino rats of Wistar strain. Rats were treated with amodiaquine (30 mg kg(-1)) and Artemisinin (2.86 mg kg(-1)) for 24 h after formation of ulcers induced by indomethacin. Treatments with Amodiaquine Hydrochloride led to significantly increased gastric lesions while artemisinin led to significantly decreased gastric lesions. Also, amodiaquine hydrochloride seemed to… Expand
Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat
It is revealed that although artesunate may be beneficial in gastric ulcer healing, its combination with either lumefantrine or amodiaquine may delay healing of gastric mucosal injury. Expand
Effect of Sulfadoxine-Pyrimethamine and Artesunate on Gastric Acid Secretion and Parietal Cell Mass in Rats
Sulfadoxine-pyrimethamine and artesunate inhibit gastric acid secretion, inhibited histamine (H2) and muscarinic (M3) receptors, and reduced parietal cell mass. Expand
Effects of quinine on gastric ulcer healing in Wistar rats
QT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion. Expand
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats
Investigation of the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction demonstrated a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries. Expand
Augmentation of gastric acid secretion by chloroquine and amodiaquine in the rat stomach.
  • K. Ajeigbe, B. Emikpe, S. Olaleye
  • Chemistry, Medicine
  • Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
  • 2012
Chloroquine and amodiaquine increased gastric acid secretion in rats and stimulated histamine (H2) and muscarinic (M3) receptors, and enhanced parietal cell mass and GMP in rats. Expand


Preliminary studies on effect of chloroquine phosphate on gastric acid secretion in rats.
It is concluded that chloroquine is a weak stimulant of gastric acid secretion rats and inhibits histamine-stimulated acid secretion probably by occupying histamine H (2) receptors in rats. Expand
Effect of a novel xanthine derivative on experimental ulcers in rats.
The data suggest that the 3-ethylxanthine A90 6119 possesses pronounced anti-ulcer activity and that its repeated administration might not aggravate ulcer formation and might reduce the incidence of recurrence. Expand
Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats.
Lead increases the formation of gastric ulcers by interfering with the oxidative metabolism in the stomach by affecting catalase and superoxide dismutase activities and the amount of nitrite in gastric mucosal samples. Expand
Effects of diets containing seeds of Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats
It was observed that G. kola produced a dose‐dependent inhibition of gastric acid secretion and indomethacin‐induced ulceration, suggesting that this might be due to its acid‐lowering effect and increased mucus production among other factors yet to be determined. Expand
Investigations of indomethacin-induced gastric ulcer in rats.
Results suggest that an overproduction of leukotrienes and other lipoxygenase products, following cyclo oxygengenase blockade induced by NSAIDs, may play a role in the development of gastric mucosal damage. Expand
Effects of indomethacin, piroxicam and selected prostanoids on gastric acid secretion by the rat isolated gastric mucosa
The potency of the thromboxane mimetic U‐46619 as an inhibitor of histamine‐induced acid secretion was markedly reduced in the presence of indomethacin, suggesting that U‐46519 may release endogenous antisecretory prostanoids. Expand
Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin.
  • L. Levine
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
  • 2001
The selective cyclooxygenase-2 (COX) inhibitor, celecoxib, and the non-selective COX-1 and COX-2 inhibitor, indomethacin, at microM concentrations, stimulate the release of arachidonic acid from ratExpand
Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
  • N. White
  • Medicine
  • Antimicrobial agents and chemotherapy
  • 1997
Malaria is unusual among the systemic infections of humans in that the number of organisms causing the disease may be quantitated with reasonable precision. This applies particularly to those causingExpand
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial
The combination of artesunate and amodiaquine improved treatment efficacy in Gabon and Kenya, and was equivalent in Sénégal, and is a potential combination for use in Africa. Expand
Antimalarial compounds: from bench to bedside
This review will summarise current antimalarial drug developments and outline recent clinical research that aims to bring artemisinin-based combinations to those that need them most. Expand