Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali

@inproceedings{Tekete2011EffectsOA,
  title={Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali},
  author={Mamadou M. Tekete and Sekou Toure and Alfia Fredericks and Abdoul Habib Beavogui and Cheick PO Sangare and Alicia L. Evans and Peter J. Smith and Hamma Maiga and Zoumana Isaac Traore and Ogobara K. Doumbo and Karen Irma Barnes and Abdoulaye A Djimde},
  booktitle={Malaria Journal},
  year={2011}
}
Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment. Yet, limited data is available on pharmacokinetic interactions between these drugs. In a randomized controlled trial, children aged 6-59 months with uncomplicated falciparum malaria, received either one dose of sulphadoxine-pyrimethamine alone (SP), one dose of SP plus three daily doses of amodiaquine… CONTINUE READING
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