Effects of ammonium acetate and sodium cholate on N-methyl-N'-nitro-N-nitrosoguanidine-induced colon carcinogenesis of rats.

Abstract

This study was conducted to determine the effects of ammonium acetate alone or in combination with sodium cholate upon N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced colon carcinogenesis in rats. Ammonia, acetate, and deconjugated bile acids are produced by microbial enzymes in the gastrointestinal lumen. One hundred twenty male Sprague-Dawley rats… (More)

Topics

Cite this paper

@article{Clinton1988EffectsOA, title={Effects of ammonium acetate and sodium cholate on N-methyl-N'-nitro-N-nitrosoguanidine-induced colon carcinogenesis of rats.}, author={Steven K. Clinton and Daniel Bostwick and Lars Olson and H J Mangian and Willard J. Visek}, journal={Cancer research}, year={1988}, volume={48 11}, pages={3035-9} }