Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.

@article{Choi2006EffectsOA,
  title={Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.},
  author={S. M. Choi and J. Kim and B. Ahn and J. Kwon},
  journal={Arzneimittel-Forschung},
  year={2006},
  volume={56 1},
  pages={
          12-7
        }
}
Hypertension is a common problem in elderly patients, which usually requires chronic therapy under various physiological conditions including low gastric acidity (hypo- or anacidity). This study investigated a new salt type of amlodipine (CAS 88150-42-9) on blood pressure and hypertension-related complications in stroke-prone spontaneously hypertensive rats (SHR-SP). Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH… Expand