Effects of aminoguanidine on latent murine tuberculosis.

  title={Effects of aminoguanidine on latent murine tuberculosis.},
  author={JoAnne L. Flynn and Charles A Scanga and K. O. Tanaka and John Chan},
  journal={Journal of immunology},
  volume={160 4},
A unique feature of Mycobacterium tuberculosis is its ability to establish latent infection in the human host, which can reactivate to cause disease years later. In the present study, the mechanisms involved in the control of latent tuberculous infection were examined using two murine experimental tuberculosis models. Analysis of the model involving infection of mice with a relatively low inoculum of the virulent Erdman strain of M. tuberculosis indicated that in vivo inhibition of reactive… CONTINUE READING

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Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases • 2015
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