Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats

  title={Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats},
  author={Jenny C. E. Owen and Peter S. Whitton},
  journal={Brain Research},
A New Strategy for Antidepressant Prescription
An understanding of the mechanism of action of antidepressants treatments (ADTs) is proposed that could improve all diseases with cognitive impairments and synaptic depression by increasing synaptic plasticity and neurogenesis.
Modulation of attention network activation under antidepressant agents in healthy subjects.
The results suggest similar effects of antidepressant treatments on behavioural and neural attentional functioning by diverging neurochemical pathways could point to basic neural mechanisms of antidepressant action irrespective of receptor profiles.
Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain
Findings from the research program investigating how neural correlates of sexual stimulus processing are modulated by serotonergic, dopaminergic, and noradrenergic antidepressant medication in healthy males are summarized.
Quantum chemical, experimental, theoretical spectral (FT-IR and NMR) studies and molecular docking investigation of 4,8,9,10-tetraaryl-1,3-diazaadamantan-6-ones
The compounds 4,8,9,10-tetraaryl-1,3-diazaadamantan-6-ones (a–e) were synthesized and characterized by FT-IR, 1H and 13C NMR spectra, and the spectral data have been theoretically analyzed by the DFT
Synthesis and Antimicrobial Activity of N′-Heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-Adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines
Compounds 4 and 5 displayed potent broad-spectrum antimicrobial activity, while compounds 3a–c showed good activity against the Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans.
Unusual Sulfuric Acid-Induced Thiol Oxidation on Dehydrative Cyclization of Potassium N′-(1-Adamantylcarbonyl)Dithiocarbazate at Room Temperature
Abstract The dehydrative cyclization of potassium N′-(1-adamantylcarbonyl)dithiocarbazate 4 with sulfuric acid was studied under several conditions. Treatment of compound 4 with sulfuric acid at room
Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 5-(1-Adamantyl)-4-arylideneamino-3-mercapto-1,2,4-triazoles and Related Derivatives
The reaction of 5-(1-adamantyl)-4-amino-3-mercapto-1,2,4-triazole with various aromatic aldehydes in ethanol or acetic acid yielded the corresponding 4-arylideneamino derivatives 6a–v and 8a–n, which were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans.


Effects of amantadine and budipine on antidepressant drug‐evoked changes in extracellular 5‐HT in the frontal cortex of freely moving rats
Combined treatment with clinically tolerated NMDA antagonists such as amantadine could reduce the delay in therapeutic onset of antidepressants as well as possibly enhance their efficacy.
Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain
Findings indicate that long-term antidepressant treatment produces region-specific changes in expression of transcripts forNMDA receptor subunits, presumably altering NMDA receptor composition.
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
The ability of antidepressants drawn from every principal therapeutic class to effect adaptive changes in the N-methyl-D-aspartate receptor complex is consistent with the hypothesis that this ligand-gated ion channel serves as a final common pathway of antidepressant action and indicates that glutamatergic pathways may be involved in the pathophysiology of depression.
Multiple mechanisms of action: the pharmacological profile of budipine.
  • M. Eltze
  • Biology, Chemistry
    Journal of neural transmission. Supplementum
  • 1999
By means of these multiple mechanisms, budipine might correct the imbalance of striatal output pathways by restoring DA levels in the striatum, and positively influence the secondary changes in other transmitter systems (glutamate, acetylcholine, GABA) observed in Parkinson's disease.