Effects of altered phosphorylation sites on the properties of CTP:phosphocholine cytidylyltransferase.

@article{Wang1995EffectsOA,
  title={Effects of altered phosphorylation sites on the properties of CTP:phosphocholine cytidylyltransferase.},
  author={Yuexi Wang and Claudia Kent},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 30},
  pages={17843-9}
}
To investigate the role of phosphorylation and dephosphorylation in modulating the activity and location of CTP:phosphocholine cytidylyltransferase, we used site-directed mutagenesis to construct four mutant forms of cytidylyltransferase. These forms were 5SP-->AP, in which five of the seven Ser-Pro sequences were converted to Ala-Pro; 7SP-->AP, in which all of the seven Ser-Pro sequences converted to Ala-Pro; 16S-->A, in which all sixteen Ser residues that can be phosphorylated in wild type… CONTINUE READING

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