Effects of altered glucocorticoid sensitivity in the T‐cell lineage on thymocyte and T‐cell homeostasis

@article{Pazirandeh2002EffectsOA,
  title={Effects of altered glucocorticoid sensitivity in the T‐cell lineage on thymocyte and T‐cell homeostasis},
  author={Ahmad Pazirandeh and Yi-le Xue and Tore Prestegaard and Mikael Jondal and Sam Okret},
  journal={The FASEB Journal},
  year={2002},
  volume={16}
}
The homeostatic regulation that controls total thymocyte and peripheral T‐cell numbers is not clearly understood. We describe here a direct hormonal influence of endogenous levels of glucocorticoids (GCs) on thymocyte and peripheral T‐cell homeostasis independent of indirect systemic effects of GCs. The results were obtained by generating transgenic mice with an altered GC sensitivity targeted to thymocytes and peripheral T cells by increasing or decreasing glucocorticoid receptor (GR… Expand
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